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Titre : | Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines (2023) |
Auteurs : | Pierre Ekobena, Auteur ; Laura E. Rothuizen, Auteur ; Francesca Bedussi, Auteur ; Pierre Guilcher, Auteur ; Sylvain Meylan, Auteur ; Alessandro Ceschi, Auteur ; François Girardin, Auteur ; Kim Dao, Auteur |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol. 62, n. 6, Juin 2023) |
Article en page(s) : | p. 587-591 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1080/14992027.2022.2056721 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Immunité ; Névrite vestibulaire ; Perte d'audition ; Vaccins contre la COVID-19 |
Résumé : |
Objective
To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines. Design Case description. Study sample We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech®) and mRNA-1273 (Moderna®) vaccines. Results Hearing loss was unilateral in all cases and recovered at least partially: it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement. Conclusions The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2022.2056721 |