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Titre : | The role of serum osmolality in Menieres disease with acute sensorineural hearing loss (2023) |
Auteurs : | Yen-Hui Lee ; Yi-Ho Young |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol. 62, n°8, Août 2023) |
Article en page(s) : | p. 713-719 |
Note générale : | https://doi-org.ezproxy.vinci.be/10.1080/14992027.2022.2075799 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Hydrops endolymphatique ; Maladie de MénièreAutres descripteurs osmolalité |
Résumé : |
This study investigated the role of serum osmolality in Menieres disease (MD) patients with acute sensorineural hearing loss (SNHL).
Design Retrospective study. Study samples Twenty definite MD patients with acute unilateral SNHL were treated with an osmotic diuretic (Isosorbide, 100 mL daily) and assigned to Group A. Another 20 age- and sex-matched definite MD patients with acute SNHL were not given Isosorbide and assigned to Group B. Both groups underwent audiometry and blood examination for serum osmolality before and after treatment. Results Group A revealed a significant increase in serum osmolality after treatment. The optimal cut-off values for increased serum osmolality in Group A were +1.5 mOSM/L for predicting hearing improvement at frequencies of 2501000 Hz, and +2.5 mOSM/L at 20004000 Hz. Comparing increased levels of serum osmolality (> +2.0 vs. ≤ +2.0 mOSM/L), Isosorbide dosing at 3.0 L vs. 1.0 L, significantly differed in the odds ratio (OR). Isosorbide at a total dosage of 3.0 L thus improves the hearing threshold by >10 dB at frequencies of 2502000 Hz. Conclusion The Isosorbide at a total dosage of 3.0 L may increase serum osmolality by > +2.0 mOSM/L, and improve the hearing threshold for hydropic ears at least >10 dB at low- and mid-frequencies. |
Disponible en ligne : | Non |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2022.2075799 |