| Titre : | Dietary Patterns and Practices and Leucocyte Telomere Length: Findings from the UK Biobank (2023) |
| Auteurs : | Vasiliki Bountziouka ; Christopher P. Nelson ; Qingning Wang ; Crispin Musicha ; Veryan Codd ; Nilesh J. Samani |
| Type de document : | Article |
| Dans : | Journal of the academy of nutrition and dietetics (Vol. 123, n° 6, June 2023) |
| Article en page(s) : | p. 912-922.e26 |
| Note générale : | https://doi.org/10.1016/j.jand.2023.01.008 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Biobanques ; Études transversales ; Leucocyte ; Régime méditerranéen ; Royaume-Uni ; Télomère |
| Résumé : |
Background : Shorter telomere length (TL) is associated with risk of several age-related diseases and decreased life span, but the extent to which dietary patterns and practices associate with TL is uncertain.
Objective : This study aimed to investigate the association of dietary patterns and practices and leucocyte TL (LTL). Design : This was a cross-sectional study. Participants and setting : Data collected voluntarily from up to 422,797 UK Biobank participants, during 2006-2010. Main outcome measures : LTL was measured as a ratio of the telomere repeat number to a single-copy gene and was loge-transformed and standardized (z-LTL). Statistical analyses performed : Adherence a priori to a Mediterranean-style diet was assessed through the MedDietScore. Principal component analysis was used to a posteriori extract the “Meat” and “Prudent” dietary patterns. Additional dietary practices considered were the self-reported adherence to “Vegetarian” diet, “Eating 5-a-day of fruit and vegetables” and “Abstaining from eggs/dairy/wheat/sugar.” Associations between quintiles of dietary patterns or adherence to dietary practices with z-LTL were investigated through multivariable linear regression models (adjusted for demographic, lifestyle, and clinical characteristics). Results : Adherence to the “Mediterranean” and the “Prudent” patterns, was positively associated with LTL, with an effect magnitude in z-LTL of 0.020 SD and 0.014 SD, respectively, for the highest vs the lowest quintile of adherence to the pattern (both P values Conclusions : Several dietary patterns and practices associated with beneficial health effects are significantly associated with longer LTL. However, the magnitude of the association was small, and any clinical relevance is uncertain. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S2212267223000175 |
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