| Titre : | A double-edged sword with a therapeutic target: iron and ferroptosis in immune regulation (2023) |
| Auteurs : | Shuo Ni ; Yin Yuan ; Shangdao Song ; Xiaolin Li |
| Type de document : | Article |
| Dans : | Nutrition reviews (Vol. 81, n° 5, May 2023) |
| Article en page(s) : | p. 587-596 |
| Note générale : | https://doi.org/10.1093/nutrit/nuac071 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Apoptose ; Arthrose ; Fer ; Mitochondries ; Peroxydation lipidique ; Rhumatisme articulaire aigu |
| Mots-clés: | Ferroptose ; régulation immunitaire |
| Résumé : | Cellular activities such as DNA synthesis, adenosine triphosphate production, and mitochondrial respiration are affected by iron metabolism. Disturbance of iron homeostasis usually leads to damage in cells and organs in the context of iron overload or deficiency. Thus, iron, a key regulator in nutritional immunity, was shown to be critical in innate and adaptive immunity. Unlike apoptosis, ferroptosis, a feature of iron-dependent lipid peroxidation, is thought to be associated with immune regulation because of its immunogenic nature. In this review, we summarize the role of iron and ferroptosis in immune regulation and discuss their therapeutic potential in the treatment of arthropathies like osteoarthritis and rheumatoid arthritis. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/5/587/6710339 |
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