| Titre : | A new prognostic model for brain metastases of specific primary tumors with stereotactic radiotherapy (2023) |
| Auteurs : | L. Gu ; S. Qing ; Huo-Jun Zhang |
| Type de document : | Article |
| Dans : | Cancer/Radiothérapie (Vol. 27, n° 3, Mai 2023) |
| Article en page(s) : | p. 183-188 |
| Note générale : | https://doi.org/10.1016/j.canrad.2022.08.009 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Carcinome pulmonaire non à petites cellules ; Métastase tumorale ; Radiochirurgie ; Radiothérapie ; Tumeurs du cerveau ; Tumeurs du poumon |
| Mots-clés: | Métastases cérébrales ; Métastases extracrinales |
| Résumé : |
Purpose
Stereotactic radiotherapy (SRT) was widely used in brain metastases (BM), especially in oligometastases. It is imperative to develop a new prognostic score to predict the overall survival (OS) of brain metastases based on prognostic factors for specific primary tumors. Material and method One hundred and ninety-seven patients were involved in the training cohort to develop a new prognostic score to predict the overall survival (OS) of brain metastases for specific primary tumors. Independent prognostic factors were confirmed using a Cox regression model. The score was developed based on clinical prognostic factors of OS with Cox proportional hazards model. The result was validated in another cohort with 56 participants to evaluate the performance of the score. Results One hundred and ninety-seven patients with 329 brain metastases received SRT. For NSCLC, the significant prognostic factors were extracranial metastases, target therapy and number of brain metastases. For gastrointestinal cancer, the significant prognostic factors were target therapy and number of brain metastases. Conclusion The prognostic factors scores were varied by the histologic types which can be used to efficiently stratify for selected patients with brain-metastasis. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321823000070 |
Bibliothèques HE Vinci
