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Titre : | Nutritional Status Assessment in Older Cancer Patients (2023) |
Auteurs : | Cecilia Medeiros de Morais |
Type de document : | Article |
Dans : | Kompass Nutrition & Dietetics (Vol. 3, n°1, 2023, April 2023) |
Article en page(s) : | p. 23-24 |
Note générale : | https://doi.org/10.1159/000529611 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Malnutrition ; Oncologie médicale ; Sujet âgé |
Mots-clés: | Global Leadership Initiative on Malnutrition (GLIM) |
Résumé : | Background & aims: Elderly cancer patients are at particularly high risk for malnutrition because both the disease and the old age threaten their nutritional status. The Global Leadership Initiative on Malnutrition (GLIM) released new universal criteria for diagnosing and grading malnutrition, but the validation of these criteria in elderly cancer population is not well documented. Our objective was to investigate the application of the GLIM criteria in nutrition assessment and survival prediction in elderly cancer patients. Methods: This retrospective cohort analysis was conducted on a primary cohort of 1192 cancer patients aged 65 years or older enrolled from a multi-institutional registry, and a validation cohort of 300 elderly cancer patients treated at the First Affiliated Hospital of Sun Yat-sen University. Patients considered at-risk for malnutrition based on the NRS-2002 were assessed using the GLIM criteria. The association between the nutritional status and patients' overall survival (OS) was then analyzed by the Kaplan-Meier method and a Cox model. A nomogram was also established that included additional independent clinical prognostic variables. To determine the predictive accuracy and discriminatory capacity of the nomogram, the C-index, receiver operating characteristic (ROC) curve and calibration curve were evaluated. Results: The percentage of patients considered at-risk for malnutrition was 64.8% and 67.3% for the primary and validation cohorts, respectively. GLIM-defined malnutrition was diagnosed in 48.4% of patients in the primary cohort and 46.0% in the validation cohort. In the primary cohort, patients at risk of malnutrition (NRS-2002 ≥ 3) showed a worse OS than those with a NRS-2002 |
Disponible en ligne : | Oui |
En ligne : | https://www.karger.com/Article/FullText/529611 |