| Titre : | Effects of conjugated linoleic acid and exercise on body composition and obesity: a systematic review and meta-analysis (2023) |
| Auteurs : | Chun-Wei Liang ; Hsiao-Yi Cheng ; Yu-Hao Lee ; Tsan-Hon Liou ; Chun-De Liao ; Shih-Wei Huang |
| Type de document : | Article |
| Dans : | Nutrition reviews (Vol. 81, n° 4, April 2023) |
| Article en page(s) : | p. 397-415 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Acides linoléiques conjugués ; Compléments alimentaires ; Composition corporelle ; Exercice physique ; Insulinorésistance ; Obésité |
| Mots-clés: | Profil lipidique |
| Résumé : |
Context: Conjugated linoleic acid (CLA) has been reported to have anti-obesity and antidiabetic effects. However, the benefits of CLA combined with exercise remain unclear, and studies report conflicting results.
Objective: A systematic review and meta-analysis were performed to investigate the synergistic effect of CLA and exercise on body composition, exercise-related indices, insulin resistance, and lipid profiles; and of the safety of CLA supplements. Data Sources: In October 2021, the PubMed, Embase, and Cochrane Library databases were searched for reports on clinical trials of the combined intervention of CLA and exercise. Data Extraction: A total of 18 randomized controlled trials and 2 crossover trials were included. The methodological quality assessment was performed using the revised Cochrane risk-of-bias tool. Pooled effect sizes were reported as standardized mean difference (SMD) for continuous data and risk ratio for dichotomous data with their corresponding 95% confidence intervals (CIs). Heterogeneity was tested using the I2 statistic. Data Analysis: The combination of CLA and exercise resulted in significantly decreased body fat (SMD, -0.42 [95%CI, -0.70, -0.14]; P = 0.003; I2 = 65) and insulin resistance (SMD, -0.25 [95%CI, -0.44, -0.06]; P = 0.01; I2 = 0) than did exercise alone. In subgroup analysis, the following factors were associated with significant outcomes: (1) body mass index ≥25 kg/m2; (2) female sex; (3) follow-up time >4 weeks; and (4) intervention duration >4 weeks. Nevertheless, supplementation with CLA during exercise programs was not effective for body-weight control, exercise performance enhancement, or lipid-profile improvement. CLA in combination with exercise did not result in a higher risk of adverse events (risk ratio, 1.32 [95%CI, 0.94-1.84]; P > 0.05; I2 = 0). Conclusion: CLA combined with exercise is generally safe and can lower body fat and insulin resistance but does not reduce body weight, enhance exercise performance, or improve lipid profiles. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/4/397/6680451 |
Bibliothèques HE Vinci
