| Titre : | Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis (2023) |
| Auteurs : | Michele Barone ; Andrea Iannone ; Fernanda Cristofori ; Vanessa Nadia Dargenio ; Flavia Indrio ; Elvira Verduci ; Alfredo Di Leo ; Ruggiero Francavilla |
| Type de document : | Article |
| Dans : | Nutrition reviews (Vol. 81, n°3, March 2023) |
| Article en page(s) : | p. 252-266 |
| Note générale : | https://doi.org/10.1093/nutrit/nuac052 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Complications ; Diagnostic ; Épidémiologie ; Indice de masse corporelle ; Maigreur ; Maladie coeliaque ; Obésité ; Prise de poids ; Régime alimentaire ; Régime sans gluten ; Surpoids |
| Résumé : |
Context: Obesity is a significant risk factor for many pathological conditions. Whether a gluten-free diet (GFD) is a risk factor for overweight or obesity remains controversial.
Objective: The primary aim of this study was to assess the prevalence of body mass index (BMI) categories at disease presentation and the variation in BMI category from underweight/normal to overweight/obese and vice versa during a GFD. Data Sources: PubMed, Scopus, and Web of Science databases were searched through February 2021 for retrospective, cross-sectional, and prospective studies reporting BMI categories at disease diagnosis and during a GFD. Data Extraction: Data were extracted by 2 reviewers independently. Disagreements were resolved by consensus; a third reviewer was consulted, if necessary. Risk of bias was assessed with the Cochrane ROBINS-I tool. Data Analysis: Subgroup analysis based on age (pediatric/adult patients), study design (prospective, cross-sectional, retrospective), and duration of GFD was performed.. Forty-five studies were selected (7959 patients with celiac disease and 20524 healthy controls). The mean BMI of celiac patients at presentation was significantly lower than that of controls (P Conclusion: Most celiac patients had a normal BMI at presentation, although the mean BMI was significantly lower than that of controls. A GFD does not increase the risk of becoming overweight/obese, especially in children. The quality of several studies was suboptimal, with moderate or high overall risk of bias and heterogeneity. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/3/252/6659924 |
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