| Titre : | Serum 25-hydroxyvitamin D levels and dyslipidemia: a systematic review and dose-response meta-analysis of epidemiologic studies (2023) |
| Auteurs : | Sedigheh Bahadorpour ; Zahra Hajhashemy ; Parvane Saneei |
| Type de document : | Article |
| Dans : | Nutrition reviews (Vol. 81, n°1, January 2023) |
| Article en page(s) : | p. 1-25 |
| Note générale : | https://doi.org/10.1093/nutrit/nuac038 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Cholestérol ; Dyslipidémies ; Études épidémiologiques ; Lipides ; Vitamine D |
| Mots-clés: | Profil lipidique ; Serum 25-hydroxyvitamin D |
| Résumé : |
Context: Findings of previous observational studies that examined the association between circulating vitamin D levels and lipid profiles have been inconsistent.
Objective: A dose-response meta-analysis of epidemiologic studies was conducted to investigate the relationship between serum 25-hydroxyvitamin D levels and dyslipidemia in adults. Data Sources: Electronic databases were searched systematically for articles published up to June 2021. Data Extraction: Fifty-seven observational studies and 2 cohort studies that reported odds ratios (ORs) or relative risks (RRs) with 95%CIs for dyslipidemia in relation to serum 25-hydroxyvitamin D levels in adults were included. Data Analysis: A high level, vs a low level, of serum 25-hydroxyvitamin D was related to a significant 19% decrease in the odds of hypertriglyceridemia (OR 0.81; 95%CI, 0.74-0.89), an 18% reduction in low high-density lipoprotein cholesterol (HDL-C) (OR 0.82; 95%CI, 0.76-0.89), and an 18% reduction in dyslipidemia (OR 0.82; 95%CI, 0.75-0.91). No significant association was found between a high vs a low level of serum 25-hydroxyvitamin D and risk of high low-density lipoprotein cholesterol (LDL-C) levels (OR 0.86; 95%CI, 0.62-1.19) or hypercholesterolemia (OR 1.03; 95%CI, 0.93-1.15). Dose-response analyses demonstrated that each 10?ng/mL increase in the serum 25-hydroxyvitamin D level was linked, respectively, to a 7% (OR 0.93;95%CI, 0.85-1.02), a 3% (OR 0.97; 95%CI, 0.90-1.05), and a 4% (OR 0.96; 95%CI, 0.92-1.00) marginally significant decrease in the odds of hypertriglyceridemia, low HDL-C, and dyslipidemia. Conclusion: Higher serum 25-hydroxyvitamin D levels are associated with significant reductions in the odds of hypertriglyceridemia, low HDL-C, and dyslipidemia in a dose-response trend. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/81/1/1/6643309 |
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