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Titre : | Construct Validity of the Steep Ramp Test for Assessing Cardiorespiratory Fitness in Patients With Breast Cancer and the Effect of Chemotherapy-Related Symptom Burden (2022) |
Auteurs : | Hester J. Van de Wiel ; Wim G. Groen ; Caroline S. Kampshoff ; Laurien M. Buffart ; Willem van Mechelen ; Goof Schep ; Gabe S. Sonke ; Rosalie Huijsmans ; Wim H. van Harten ; Neil K. Aaronson ; Martijn M. Stuiver |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (Vol. 103, n° 12, 2022) |
Article en page(s) : | p. 2362-2367 |
Note générale : | https://doi.org/10.1016/j.apmr.2022.05.014 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Epreuve d'effort ; Réadaptation ; Tumeurs du sein |
Résumé : |
Objective
To investigate the construct validity of the Steep Ramp Test (SRT) by longitudinally comparing the correlation between maximum short exercise capacity of the SRT and direct measurements of peak oxygen consumption (Vo2peak) during or shortly after treatment in patients with breast cancer and the potential effect of chemotherapy-induced symptom burden. Design Cross-sectional. Setting Multicenter. Participants We used data from 2 studies that included women with breast cancer treated with chemotherapy, resulting in 274 observations. A total of 161 patients (N=161) performed the cardiopulmonary exercise test and the SRT in 2 test sessions on different time points around chemotherapy treatment. Interventions Not applicable. Main Outcome Measures Fatigue was assessed with the Multidimensional Fatigue Inventory, and nausea and vomiting and pain by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30. The longitudinal correlation between the maximum short exercise capacity and Vo2peak was investigated using a linear mixed model. Interaction terms were added to the model to investigate whether the correlation varied by symptom burden. Results We found a statistically significant moderate correlation between Vo2peak and maximum short exercise capacity (0.61; 95% confidence interval, 0.51-0.70; P<.01 over time. this correlation was slightly attenuated confidence interval to p=".04)" in patients with chemotherapy-related nausea and vomiting indicating smaller correlations of vo2peak the maximum short exercise capacity increasing symptom burden. pain fatigue did not significantly modify correlation.> Conclusions The SRT can only be used as a proxy for changes in aerobic capacity with great caution and with attention for the level of nausea and vomiting. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999322004658 |