| Titre : | Association of dietary factors with plasma homocysteine and coronary heart disease outcome (2022) |
| Auteurs : | Rizwana Muzaffar ; Muhammad Athar Khan ; Muhammad Hassan Mushtaq ; Muhammad Nasir ; Mamoona Chaudhry ; Muhammad Fayaz Khan ; Amjad Khan |
| Type de document : | Article |
| Dans : | Nutrition clinique et métabolisme (Vol. 36, n°2, Mai 2022) |
| Article en page(s) : | p. 106-111 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Acide folique ; Homocystéine ; Maladie coronarienne ; Vitamine B12 ; Vitamine B6 |
| Mots-clés: | Facteurs alimentaires |
| Résumé : |
Objective
The aim of the present study was to investigate the association between serum levels of vitamins B12, B6, folic acid and hyperhomocysteinemia with the risk of coronary heart disease (CHD). Material and methods A case control study was carried out involving 105 newly diagnosed coronary heart disease patient of both gender (age range 25–60 years) and 105 age and sex matched normal healthy individuals at Punjab Institute of Cardiology, Lahore. Fasting blood samples were collected from both cases and controls. Sera were analyzed for folic acid, vitamin B6 and B12 using high performance liquid chromatography (HPLC). Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) and traditional risk factors were also assessed. Results Mean plasma homocysteine level in cases (22.33 ± 9.22 μmol/L) was significantly higher (P = 0.0001) than controls (12.5 ± 3.73 μmol/L). Mean serum folic acid concentration, serum vitamin B6 and vitamin B12 were significantly lower in cases than the mean levels in controls (P Conclusion Nutritional deficiency of folic acid, vitamin B12 and B6 were common in coronary heart disease patients with an inverse correlation of plasma homocysteine concentration with these vitamins. Substantial deficiency of these vitamins along with hyperhomocysteinemia could be further aggravating the risk of CHD in Pakistani population. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0985056222000152 |
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