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Titre : | Randomization to Treadmill Training Improves Physical and Metabolic Health in Association With Declines in Oxidative Stress in Stroke (2022) |
Auteurs : | Monica C. Serra ; Charlene E. Hafer-Macko ; Ronna Robbins ; Jason C. O'Connor ; Alice S. Ryan |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (Vol. 103, n° 11, 2022) |
Article en page(s) : | p. 2077-2084 |
Note générale : | https://doi.org/10.1016/j.apmr.2022.06.011 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Accident vasculaire cérébral (AVC) ; Exercice physique ; Inflammation ; Réadaptation ; Stress oxydatif |
Résumé : |
Objective
To investigate the effect of aerobic exercise vs control (stretching/balance) on inflammatory and oxidative stress biomarkers in stroke survivors and whether these changes are associated with improvements in physical and metabolic health. Design Randomized controlled trial. Setting The general communities of Baltimore, Maryland, and Atlanta, Georgia. Participants Two hundred forty-six older (>50 years), chronic (>6 months) survivors of stroke (N=246) with hemiparetic gait were recruited, with 51 completing pre-intervention testing and 39 completing postintervention testing. Participants were required to have completed all conventional physical therapy and be capable of walking 3 minutes on a treadmill (N=246). Intervention Participants completed 6 months of 2 times/wk stretching or balance (ST; n=19) or 3 times/wk aerobic treadmill rehabilitation (TM; n=20;). Main Outcome Measure(s) Peak oxygen uptake rate (V̇o2peak), 6-minute walking distance (6MWD), fasting plasma glucose, insulin, oxidative stress, and inflammatory biomarkers were assessed pre- and postintervention. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) was calculated. Results Physical function and metabolic health parameters tended to improve after TM but not ST (ST vs TM: V̇o2peak: −9% vs 24%, P<.01 vs p=".05;" insulin: homa-ir: plasma concentrations of nitrotyrosine protein carbonyls and oxidized low-density lipoprotein tended to decrease from pre-intervention in response tm compared st tm: nitrotyrosine: carbonyls: oxldl: changes circulating c-reactive oxldl were negatively associated with v positively fasting insulin homa-ir ps> Conclusions Six months of TM tends to be associated with increased functional capacity and reduced oxidative stress in chronic stroke survivors. Our findings identify potentially modifiable systemic markers of inflammation and oxidative stress important to stroke rehabilitation and provide potential targets for novel therapeutics in future studies. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999322005172 |