| Titre : | Preliminary Investigation of Microbiome and Dietary Differences in Patients with Phenylketonuria on Enzyme Substitution Therapy Compared to Traditional Therapies (2022) |
| Auteurs : | Nicole McWhorter ; Jaapna Dhillon ; Jessie Hoffman |
| Type de document : | Article |
| Dans : | Journal of the academy of nutrition and dietetics (Vol. 122, n°7, July 2022) |
| Article en page(s) : | p. 1283-1295.e3 |
| Note générale : | https://doi.org/10.1016/j.jand.2021.12.011 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Adulte ; Études transversales ; Microbiome gastro-intestinal ; Régime alimentaire |
| Mots-clés: | Thérapie enzymatique substitutive ; Phenylalanine ammonia-lyase ; Phénylalanine ; Phénylcétonuries ; Phenylalanine Hydroxylase ; protéines recombinantes |
| Résumé : | Background Phenylketonuria (PKU) is an inborn error of metabolism that impairs the function of the enzyme phenylalanine hydroxylase. Historical treatment includes limiting dietary phenylalanine (Phe) consumption while supplementing with medical food; however, this treatment has been associated with complications, such as nutritional deficiencies and disruptions in the gut microbiota. Objective The study aim was to compare dietary and gut microbiome differences between adult patients on a traditional PKU diet with those receiving the enzyme substitution therapy Palynziq on a liberalized diet while controlling blood Phe levels to |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S2212267221015732 |
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