| Titre : | Cerebellar Contributions to Motor and Cognitive Control in Multiple Sclerosis (2022) |
| Auteurs : | Nora E. Fritz ; Erin M. Edwards ; Chuyang Ye ; Jerry Prince ; Zhen Yang ; Timothy Gressett ; Jennifer Keller ; Emily Myers ; Peter A. Calabresi ; Kathleen M. Zackowski |
| Type de document : | Article |
| Dans : | Archives of Physical Medicine and Rehabilitation (Vol. 103, n° 8, 2022) |
| Article en page(s) : | p. 1592-1599 |
| Note générale : | https://doi.org/10.1016/j.apmr.2021.12.010 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Cervelet ; Cognition ; Imagerie par résonance magnétique ; Imagerie par tenseur de diffusion ; Réadaptation ; Sclérose en plaques |
| Résumé : |
Objective
To evaluate relationships between specific cerebellar regions and common clinical measures of motor and cognitive function in persons with multiple sclerosis (PwMS). Design Cross-sectional. Setting Laboratory. Participants Twenty-nine PwMS and 28 age- and sex-matched controls without multiple sclerosis (MS) (N=57). Interventions Not applicable. Main Outcome Measures Both diffusion and lobule magnetic resonance imaging analyses and common clinical measures of motor and cognitive function were used to examine structure-function relationships in the cerebellum. Results PwMS demonstrate significantly worse motor and cognitive function than controls, including weaker strength, slower walking, and poorer performance on the Symbol Digit Modalities Test, but demonstrate no differences in cerebellar volume. However, PwMS demonstrate significantly worse diffusivity (mean diffusivity: P=.0003; axial diffusivity: P=.0015; radial diffusivity: P=.0005; fractional anisotropy: P=.016) of the superior cerebellar peduncle, the primary output of the cerebellum. Increased volume of the motor lobules (I-V, VIII) was significantly related to better motor (P<.022 and cognitive performance increased volume of the lobules was also related to better motor supporting role cerebellum in both functioning.> Conclusions These data highlight the contributions of the cerebellum to both motor and cognitive function in PwMS. Using novel neuroimaging techniques to examine structure-function relationships in PwMS improves our understanding of individualized differences in this heterogeneous group and may provide an avenue for targeted, individualized rehabilitation aimed at improving cerebellar dysfunction in MS. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999321017731#! |
Bibliothèques HE Vinci
