Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | Fecal Microbiota Transplantation for The Early-Onset Type 1 Diabetes. Could It Be a Promising Solution? (2022) |
Auteurs : | Arezina Kasti |
Type de document : | Article |
Dans : | Kompass Nutrition & Dietetics (Vol. 2, n° 1, 2022, April 2022) |
Article en page(s) : | p. 92-105 |
Note générale : | https://doi.org/10.1159/000522521 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Diabète de type 1 ; Insuline ; Microbiome gastro-intestinal ; Microbiote ; Transplantation de microbiote fécal |
Résumé : |
Objective: Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiotaimmunological interplay is involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression in patients with type 1 diabetes using faecal microbiota transplantation (FMT).
Design: Patients with recent-onset ( Results: Stimulated C peptide levels were significantly preserved in the autologous FMT group (n = 10 subjects) compared with healthy donor FMT group (n = 10 subjects) at 12 months. Small intestinal Prevotella was inversely related to residual beta cell function (r = −0.55, p = 0.02), whereas plasma metabolites 1-arachidonoyl-GPC and 1-myristoyl-2-arachidonoyl-GPC levels linearly correlated with residual beta cell preservation (rho = 0.56, p = 0.01 and rho = 0.46, p = 0.042, respectively). Finally, baseline CD4 +CXCR3+T cell counts, levels of small intestinal Desulfovibrio piger and CCL22 and CCL5 gene expression in duodenal biopsies predicted preserved beta cell function following FMT irrespective of donor characteristics. Conclusion: FMT halts decline in endogenous insulin production in recently diagnosed patients with T1D in 12 months after disease onset. Several microbiota-derived plasma metabolites and bacterial strains were linked to preserved residual beta cell function. This study provides insight into the role of the intestinal gut microbiome in T1D. |
Disponible en ligne : | Oui |
En ligne : | https://www.karger.com/Article/FullText/522521 |