| Titre : | Ototoxicity After Cisplatin-Based Chemotherapy: Factors Associated With Discrepancies Between Patient-Reported Outcomes and Audiometric Assessments (2022) |
| Auteurs : | Shirin Ardeshirrouhanifard ; Sophie D. Fossa ; Robert Huddart ; Patrick O. Monahan ; M. Eileen Dolan ; Robert J. Hamilton ; David Vaughn ; Neil Martin ; Christian Kollmannsberger ; Paul Dinh ; Lawrence Einhorn ; Lois B. Travis ; Robert D. Frisina ; Darren R. Feldman ; Yiqing Song ; Chunkit Fung |
| Type de document : | Article |
| Dans : | Ear and hearing (Vol. 43, n°3, Mai-juin 2022) |
| Article en page(s) : | p. 794-807 |
| Note générale : | 10.1097/AUD.0000000000001172 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Cisplatine ; Ototoxicité ; Survivants du cancer ; Tumeurs du testicule |
| Résumé : |
Objectives: To provide new information on factors associated with discrepancies between patient-reported and audiometrically defined hearing loss (HL) in adult-onset cancer survivors after cisplatin-based chemotherapy (CBCT) and to comprehensively investigate risk factors associated with audiometrically defined HL.
Design: A total of 1410 testicular cancer survivors (TCS) >=6 months post-CBCT underwent comprehensive audiometric assessments (0.25 to 12 kHz) and completed questionnaires. HL severity was defined using American Speech-Language-Hearing Association criteria. Multivariable multinomial regression identified factors associated with discrepancies between patient-reported and audiometrically defined HL and multivariable ordinal regression evaluated factors associated with the latter. Results: Overall, 34.8% of TCS self-reported HL. Among TCS without tinnitus, those with audiometrically defined HL at only extended high frequencies (EHFs) (10 to 12 kHz) (17.8%) or at both EHFs and standard frequencies (0.25 to 8 kHz) (23.4%) were significantly more likely to self-report HL than those with no audiometrically defined HL (8.1%) [odds ratio (OR) = 2.48; 95% confidence interval (CI), 1.31 to 4.68; and OR = 3.49; 95% CI, 1.89 to 6.44, respectively]. Older age (OR = 1.09; 95% CI, 1.07 to 1.11, p 300 mg/m2, OR = 1.47; 95% CI, 1.21 to 1.80, p = 0.0001), and hypertension (OR = 1.80; 95% CI, 1.28 to 2.52, p = 0.0007) were associated with greater American Speech-Language-Hearing Association-defined HL severity, whereas postgraduate education (OR = 0.58; 95% CI, 0.40 to 0.85, p = 0.005) was associated with less severe HL. Conclusions: Discrepancies between patient-reported and audiometrically defined HL after CBCT are due to several factors. For survivors who self-report HL but have normal audiometric findings at standard frequencies, referral to an audiologist for additional testing and inclusion of EHFs in audiometric assessments should be considered. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=toc&D=yrovft&AN=00003446-000000000-00000 |
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