| Titre : | Efficacy and safety of hypofractionated stereotactic radiotherapy for brain metastases using three fractions: A single-centre retrospective study (2021) |
| Auteurs : | E. Vigneau ; J. Jacquemin ; B. Benadon ; T. Dat Nguyen ; C. Marchand-Créty |
| Type de document : | Article |
| Dans : | Cancer/Radiothérapie (vol. 25, no. 8, Décembre 2021) |
| Article en page(s) : | p.763-770 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Métastase tumorale ; Radiochirurgie ; Radiothérapie ; Tumeurs du cerveau |
| Mots-clés: | Métastases cérébrales ; fractionnement de la dose d'irradiation |
| Résumé : |
/Purpose
Hypofractionated stereotactic radiotherapy (HFSRT) has become a standard of care for patients with a limited number of brain metastases (BM). An increasing number of linear accelerators (LA) are able to accurately perform HFSRT including VersaHD® (Elekta®) LA. The main aim of this study was to report clinical outcomes of BM treated by HFSRT using 3*7.7Gy on 70% isodose line in terms of local control (LC). /Patients and methods Between November 2016 and October 2018, all patients suffering from histologically-proven primary with one or several newly diagnosed BM treated by HFSRT were retrospectively included and evaluated. Patients who had received prior treatment by neurosurgery or cerebral radiotherapy were excluded. /Results Among 44 patients, 61 BM were treated. With a median follow-up of 31.9 months, LC rates at 6 and 12 months were 93.2% and 90.9, respectively. Single-BM was independently predictive of LC (P=0.025) and overall survival (P=0.013). Acute toxicity rates were acceptable: 65.9% of patients had grade 1 and 2 and no acute grade 3 toxicity according to the NCI-CTCAE (version 5.0). Regarding delayed toxicity, one case (2.3%) of radionecrosis was confirmed by magnetic resonance spectroscopy. /Conclusion In our single-centre retrospective analysis, BM treatment by HFSRT delivered in three fractions showed a 12-month LC rate of 90.9% without major toxicities, which suggests safety and efficiency of this technique. However, longer-term follow-up and prospective studies are still needed to confirm these results. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1278321821000901 |
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