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Titre : | Combined effect of Controlling Nutritional Status and Acute Kidney Injury on severe COVID-19 short-term outcomes (2021) |
Type de document : | Article |
Dans : | Nutrition clinique et métabolisme (Vol. 35, n° 2, Mai 2021) |
Article en page(s) : | p.144-151 |
Note générale : | https://doi.org/10.1016/j.nupar.2021.03.001 |
Langues: | Anglais |
Descripteurs : |
HE Vinci COVID-19 ; Insuffisance rénale ; Mortalité |
Mots-clés: | atteinte rénale aigüe ; insuffisance rénale aiguë ; Controlling Nutritional Status (CONUT) ; Mortalité à court terme |
Résumé : |
Introduction/Objectives
Acute kidney injury (AKI) and malnutrition are two complications commonly reported in severe forms of COVID-19, their combined effect on short-term mortality is, however, not yet investigated. The objective of this study is to determine both their individual and combined effects on short-term prognosis. Materials and methods This is a prospective, uni-centric study, including 247 severe COVID-19 patients, admitted between April 25th and June 20th, 2020, at the University Hospital of Blida. AKI was defined according to the KDIGO-2012 guidelines. Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score. The association with in-hospital mortality was assessed using the Kaplan-Meier method and proportional Cox regression. Results Among the 247 severely affected COVID-19 patients included in this study, 34.4% developed AKI, 30.4 and 1.2%, respectively, had moderate and severe CONUT scores, 17.7% worsened and progressed to a critical state and 26.7% did not survive. Both AKI and CONUT score were significantly associated with mortality in a dose-response manner (pLog-Rank Conclusion A possible synergistic interaction between AKI and CONUT score for COVID-19 short-term mortality has been highlighted. Monitoring of renal function associated with assessment of nutritional status should be performed routinely and systematically from the early stages of admission. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0985056221001175 |