| Titre : | Carnosine and histidine-containing dipeptides improve dyslipidemia: a systematic review and meta-analysis of randomized controlled trials (2020) |
| Auteurs : | Kirthi Menon ; Clara Marquina ; Pernille Hoj ; Danny Liew ; Aya Mousa ; Barbora De Courten |
| Type de document : | Article |
| Dans : | Nutrition reviews (Vol. 78, n° 11, November 2020) |
| Article en page(s) : | p. 939–951 |
| Note générale : | doi:10.1093/nutrit/nuaa022 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Carnosine ; Dipeptides ; Histidine ; Maladies cardiovasculaires |
| Résumé : |
Context:
Cardiovascular disease is a major public health problem and represents a significant burden of disease globally. Lifestyle interventions have their limitations and an intervention that will effectively address cardiovascular risk factors to help reduce this growing burden of disease is required. Objective: Carnosine and other histidine-containing dipeptides (HCDs) have exerted positive effects on cardiovascular risk factors and diseases in animal and human studies. The authors conducted a systematic review and meta-analysis examining the effects of HCDs on cardiovascular outcomes in line with the PRISMA guidelines. Data Sources: The Medline, Medline in process, Embase, Cumulative Index of Nursing and Allied Health, and All EBM databases were searched from inception until January 25, 2019, for randomized controlled trials (RCTs) examining the effects of HCDs on cardiovascular outcomes, compared with placebo or controls. Data Extraction: Basic characteristics of the study and populations, interventions, and study results were extracted. The grading of recommendations assessment, development, and evaluation approach was used to assess the quality of evidence for each outcome. Data Analysis: A total of 21 studies were included. Of these, 18 were pooled for meta-analysis (n = 913). In low risk of bias studies, HCD-supplemented groups had lower total cholesterol (n = 6 RCTs; n = 401; weighted mean difference [WMD], −0.32 mmol/L [95%CI, −0.57 to −0.07], P = 0.01) and triglyceride levels (n = 6 RCTs; n = 401; WMD, −0.14 mmol/L [95%CI, −0.20 to −0.08], P Conclusions: Carnosine and other HCDs may have a role in improving lipid profiles. Larger studies with sufficient follow-up are necessary to confirm these findings and explore the use of HCDs in the prevention of cardiovascular diseases. |
| Disponible en ligne : | Oui/Non |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/78/11/939/5864433 |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|
| Nutrition reviews. Vol. 78, n° 11 (November 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |
