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Titre : | Cyanidin-3-glucoside as a possible biomarker of anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials (2020) |
Auteurs : | Berner-Andrée Sandoval-Ramírez ; Ursula Catalán ; Sara Fernández-Castillejo ; Anna Pedret ; Elisabet Llaurado ; Rosa Sola |
Type de document : | Article |
Dans : | Nutrition reviews (Vol. 78, n° 7, July 2020) |
Article en page(s) : | p. 597610 |
Note générale : | doi:10.1093/nutrit/nuz083 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Anthocyanes ; Baies (fruit) ; Marqueurs biologiques ; Plasma sanguin ; Urine |
Mots-clés: | Cyanidin 3-O-glucoside |
Résumé : |
Context:
Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far. Objective: The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine. Data Sources: PubMed and Cochrane databases were searched from January 2008 to January 2019. Study Selection: Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded. Data Extraction: Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve. Results: Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P = 0.210) in plasma, which is acceptable, and 61.7% (P = 0.402) in urine. Conclusions: Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://academic.oup.com/nutritionreviews/article/78/7/597/5681776 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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Nutrition reviews. Vol. 78, n° 7 (July 2020) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |