| Titre : | Synchrotron Radiation-Based Reconstruction of the Human Spiral Ganglion: Implications for Cochlear Implantation (2020) |
| Auteurs : | Hao Li ; Nadine Schart-Moren ; Seyed Alireza Rohani ; Hanif M. Ladak ; Helge Rask-Andersen ; Sumit Agrawal |
| Type de document : | Article |
| Dans : | Ear and hearing (Vol. 41, n°1, Janvier-Février 2020) |
| Article en page(s) : | p. 173-181 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Cochlée ; Ganglion ; SynchrotronsAutres descripteurs Organe de Corti |
| Résumé : |
Objective: To three-dimensionally reconstruct Rosenthal's canal (RC) housing the human spiral ganglion (SG) using synchrotron radiation phase-contrast imaging (SR-PCI). Straight cochlear implant electrode arrays were inserted to better comprehend the electro-cochlear interface in cochlear implantation (CI).
Design: SR-PCI was used to reconstruct the human cochlea with and without cadaveric CI. Twenty-eight cochleae were volume rendered, of which 12 underwent cadaveric CI with a straight electrode via the round window (RW). Data were input into the 3D Slicer software program and anatomical structures were modeled using a threshold paint tool. Results: The human RC and SG were reproduced three-dimensionally with artefact-free imaging of electrode arrays. The anatomy of the SG and its relationship to the sensory organ (Corti) and soft and bony structures were assessed. Conclusions: SR-PCI and computer-based three-dimensional reconstructions demonstrated the relationships among implanted electrodes, angular insertion depths, and the SG for the first time in intact, unstained, and nondecalcified specimens. This information can be used to assess stimulation strategies and future electrode designs, as well as create place-frequency maps of the SG for optimal stimulation strategies of the human auditory nerve in CI. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=toc&D=yrovft&AN=00003446-000000000-00000 |
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