| Titre : | Current management of stage I testicular germ cell tumors in a French cancer institute. A practice analysis over the 10 past years (2019) |
| Titre original: | Prise en charge des tumeurs germinales de stade I dans un institut français. Analyses des pratiques au cours des 10 dernières années |
| Auteurs : | Edouard Chanal ; Wafa Bouleftour ; Aline Guillot ; Elise Rowinski ; Emilie Bernichon ; Lancelot Tremeau ; Renaud Lardon ; Bertrand Lacroix ; Stéphane Lorin ; Grégory Delorme ; Yves Perraud ; Corinne Armand ; Frederic Levigne ; Alexis Vallard ; Julien Langrand-Escure ; Pierre Fournel ; Benoite Méry ; Cecile Vassal |
| Type de document : | Article |
| Dans : | Bulletin du cancer (Vol. 106, n° 12, Décembre 2019) |
| Article en page(s) : | p. 1086-1093 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Équipe soignante ; Etablissement de cancérologie ; Études rétrospectives ; Evaluation des pratiques professionnelles ; France ; Hommes ; Influenceur (réseaux sociaux) ; Normes ; Orchidectomie ; Radio-oncologie ; Recherche biomédicale ; Surveillance ; Tumeurs du testicule |
| Résumé : |
Background
Testicular Germ Cell Tumors (TGCTs) represent the most frequent malignant tumour among young male adults. Orchiectomy alone cure 80% of stage I. Standard options after orchiectomy include radiotherapy (RT), chemotherapy (CT) by 1 cycle of carboplatin AUC 7 or active surveillance (SV) for seminomatous GCTs (SGCT) and retroperitoneal lymphadenectomy (RPLND), CT by 1 or 2 cycles of Bleomycine Etoposide Cisplatine (BEP) or active surveillance for nonseminomatous GCTs (NSGCT). Adjuvant treatments decrease the relapse rate after orchiectomy with substantial toxicities without any benefit on overall survival. Recent guidelines accorded utmost importance on SV rather than adjuvants strategies. The main objective of this study was to describe our current practice over the 10 past years in regard of these recommendations. Methods Data of 50 patients with stage I GCT treated in our institute were collected between 2006 and 2016. Demographic and anatomopathologic data were reported. Clinical practice in our center was analyzed during two periods [2006–2011] and [2012–2016] according to the European Association of Urology Guidelines in 2011. Results Patient's median age was 35.3 years. The analysis of clinical practice during the last 10 years showed that in SGCT, main treatment was RT than SV and CT. This option declined over the years (89% between 2006–2010 versus 53% between 2011–2016) whereas SV was more often employed (27% between 2011-2016 versus none between 2006–2010). Surveillance was used for 64% of NSGCT. Conclusions In our center, RT was less used over the years for the benefit of SV which is recommended by guidelines. |
| Disponible en ligne : | Non |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|
| Bulletin du cancer. Vol. 106, n° 12 (Décembre 2019) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |
