| Titre : | HER2-specific chimeric antigen receptor-engineered natural killer cells combined with apatinib for the treatment of gastric cancer (2019) |
| Auteurs : | Xian Wu ; Shucheng Huang |
| Type de document : | Article |
| Dans : | Bulletin du cancer (Vol. 106, n° 11, Novembre 2019) |
| Article en page(s) : | p. 946-958 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Récepteurs chimériques pour l'antigène ; Tumeurs de l'appareil digestif |
| Résumé : |
Aim : A HER2-specific second-generation chimeric antigen receptor (5.137.z) was introduced into NK-92 cells, designated as NK-92/5.137.z cells. To evaluate the function and effectiveness of NK-92/5.137.z cells against gastric cancer cells and further determined whether combination with apatinib can synergize with this NK cell-based practice to better suppress gastric cancer.
Methods :The expression of HER2 was examined in gastric cancer. The in vitro and in vivo cytotoxic activities of NK-92/5.137.z cells with or without apatinib were evaluated against gastric cancer cell lines. |
| Disponible en ligne : | Non |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|
| Bulletin du cancer. Vol. 106, n° 11 (Novembre 2019) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |
