| Titre : | The Association of Performance Status and Disease Severity in Patients With Chronic Graft-vs-Host Disease (2019) |
| Auteurs : | Cody Andrews ; Sean Smith ; Maggi Kennel |
| Type de document : | Article |
| Dans : | Archives of Physical Medicine and Rehabilitation (Vol. 100, n° 4, 2019) |
| Article en page(s) : | p. 606-612 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Indice de performance de Karnofsky ; Qualité de vie ; Rééducation et réadaptation ; Transplantation de cellules souches hématopoïétiques |
| Résumé : |
Objective
Determine the relationship between functional status and degree of specific organ involvement, physical performance, and subjective well-being chronic graft-vs-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation. Design Observational cohort. Setting Outpatient clinic. Participants Adult patients (N=121) with cGVHD with 634 assessments. Interventions Not applicable. Main Outcome Measures Karnofsky Performance Status (KPS). Skin, fascia/joints, lungs, upper and lower extremity range of motion, liver, eye, mucosal, and gastrointestinal involvement were measured using the National Institutes of Health GVHD scale. Physical performance was assessed with the 2-minute walk test (2MWT) and hand grip strength. Subjective measures were the Patient Health Questionnaire 9 (PHQ-9) and Lee Symptom Burden (LSB) scale. Results Myofascial (P<.001 and lung involvement lsb phq-9 had the largest associations with kps liver hand grip strength more modest kps.> Conclusions Patients with cGVHD experience multifactorial impairment in function associated with potentially modifiable symptoms physiatrists have the expertise to address to enhance function. More research is needed to determine rehabilitation interventions to mitigate the impact of cGVHD on function. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999318311870 |
Bibliothèques HE Vinci
