trié(s) par (Pertinence décroissant(e), Titre croissant(e)) 

Article

D-methionine administered as late as 36;hours post-noise exposure rescues from permanent threshold shift and dose-dependently increases serum antioxidant levels

Kathleen C. M. Campbell, Auteur ; Nicole Cosenza, Auteur ; Robert Meech, Auteur ; Michael Buhnerkempe, Auteur ; Jun Qin, Auteur ; Leonard Rybak, Auteur ; Daniel J. Fox, Auteur |

Dans International Journal of Audiology IJA (Vol. 62, no. 2, Février 2023)

Objective To elucidate D-methionine’s (D-met) dose and time rescue parameters from steady-state or impulse noise-induced permanent threshold shift (PTS) and determine D-met rescue’s influence on serum and cochlear antioxidant levels. Design [...]

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Article

D-methionine immediate and continued rescue after noise exposure does not prevent temporary threshold shift but alters cochlear and serum antioxidant levels

Kathleen C. M. Campbell ; Nicole Cosenza ; Robert Meech ; Michael Buhnerkempe ; Jun Qin ; Leonard Rybak ; Daniel J. Fox |

Dans International Journal of Audiology IJA (vol. 61, no. 9, septembre 2022)

Objective Determine if D-methionine (D-met) rescue prevents temporary threshold shift (TTS) from steady-state or impulse noise and determine D-met’s impact on serum and cochlear antioxidant levels. Design D-met at 50, 100 or 200 mg/kg/d[...]

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Article

Oral D-methionine protects against cisplatin-induced hearing loss in humans: phase 2 randomized clinical trial in India

Kathleen C. Campbell ; Alnawez Rehemtulla ; Prasad Sunkara ; Daniel Hamstra ; Michael Buhnerkempe ; Brian Ross |

Dans International Journal of Audiology IJA (vol. 61, no. 8, août 2022)

Objective: This exploratory Phase 2 clinical trial is the first determining safety and efficacy of oral D-methionine (D-met) in reducing cisplatin-induced ototoxicity. Design: Randomised parallel double-blind placebo-controlled exploratory Phas[...]

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