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Titre : | Negative hearing effects of a single course of IV aminoglycoside therapy in cystic fibrosis patients (2018) |
Auteurs : | Malcolm A. Gleser ; Erika M. Zettner |
Type de document : | Article |
Dans : | International Journal of Audiology IJA (Vol. 57, n°1-12, January-December 2018) |
Article en page(s) : | p. 923-930 |
Langues: | Anglais |
Résumé : |
Objective: Identify hearing effects of a single course of intravenous (IV) aminoglycoside antibiotics (AGs) therapy in adult cystic fibrosis (CF) patients. Determine whether the change is large enough to enable a proof-of-concept study of a new drug preventing AG-associated hearing loss. Design: Retrospective case review of CF patients with sequential audiograms + an intervening course of IV AG therapy. Study sample: 84 patients with no intervening IV AG treatment, 38 patients undergoing a single course of IV AGs. Results: Using ASHA ototoxicity metrics, 45% of adult CF patients in the Single-IV group met the criteria for ototoxicity compared to 23% of the No-IV patients. Other hearing metrics including the average maximal threshold shift (TS) and average high frequency TS showed highly significant differences between groups. Testing only participants with mild or greater pre-therapy high frequency hearing loss further increased the differences between the two groups by every metric tested. Conclusion: Adult CF patients exposed to a single course of IV AGs have significantly greater TS than patients without IV AG exposure. Patients with mild to moderate hearing loss prior to AG-IVs are at increased risk of developing ototoxicity from subsequent parenteral AG therapy. |
Accès : | Contactez la bibliothèque d'Ixelles si le lien vers la ressource électronique ne fonctionne plus |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.tandfonline.com/doi/full/10.1080/14992027.2018.1514537 |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
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International journal of audiology IJA. Vol. 57, n°1-12 (January-December 2018) | Périodique papier | Ixelles | Rez | Consultation sur place uniquement Exclu du prêt |