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Titre : | Pulsed electromagnetic field ameliorates cartilage degeneration by inhibiting mitogen-activated protein kinases in a rat model of osteoarthritis (2017) |
Auteurs : | Jun Zhou ; Yuan Liao ; Haitao Xie ; et al. |
Type de document : | Article |
Dans : | Physical therapy in sport (2017/2, March 2017) |
Article en page(s) : | p. 32-38 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Arthrose ; Experimentation ; Rat |
Mots-clés: | Champs électromagnétique pulsé ; Dégénérescence du cartilage ; Inhibition des protéines |
Résumé : |
Objectives We assessed the effects of pulsed electromagnetic field (PEMF) on cartilage degeneration, and expression of mitogen-activated protein kinases (MAPKs) and matrix metalloproteinases (MMPs), in an experimental rat model of osteoarthritis induced by anterior cruciate ligament transection (ACLT). Design Experimental. Setting University animal laboratory. Participants 30 male SpragueDawley rats. Main Outcome Measures We performed histological examination, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, to assess cartilage degeneration, urine C-terminal cross-linking telopeptide of type II collagen (CTX-II), and mRNA expression of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (c-Jun), p38, and MMPs. Results Urinary CTX-II in the PEMF group was significantly lower than in the ACLT group at 9 and 13 weeks. Mankin scores in the PEMF group significantly lower than that in the ACLT group (P Conclusions PEMF may regulate the catabolic factor, MMP13, and inhibit cartilage destruction, at least partially, by inhibiting MAPKs signaling pathway. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S1466853X16301328 |