| Titre : | Single-Fiber Electromyography Analysis of Botulinum Toxin Diffusion in Patients With Fatigue and Pseudobotulism (2015) |
| Auteurs : | Alexis Ruet ; Marie Christine Durand ; Pierre Denys |
| Type de document : | Article |
| Dans : | Archives of Physical Medicine and Rehabilitation (2015/6, 2015) |
| Article en page(s) : | p. 1103–1109 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Asthenie ; Botulisme ; Electromyographie ; Rééducation et réadaptation |
| Mots-clés: | Asthenia ; Botulinum toxins ; type A ; Toxines botuliniques de type A ; Botulism ; Electromyography |
| Résumé : |
Objective To characterize electromyographic abnormalities according to symptoms (asymptomatic, fatigue, pseudobotulism) reported 1 month after botulinum toxin injection. Design Retrospective, single-center study comparing single-fiber electromyography (SFEMG) in the extensor digitorum communis (EDC) or orbicularis oculi (OO) muscles. Setting Hospital. Participants Four groups of adults treated for spasticity or neurologic bladder hyperactivity (N=55): control group (asymptomatic patients: n=17), fatigue group (unusual fatigue with no weakness: n=15), pseudobotulism group (muscle weakness and/or visual disturbance: n=20), and botulism group (from intensive care unit of the same hospital: n=3). Interventions Not applicable. Main Outcome Measures Mean jitter, percentage of pathologic fibers, and percentage of blocked fibers were compared between groups. Results SFEMG was abnormal for 17.6% of control patients and 75% of patients in the pseudobotulism group. There were no differences between the control and fatigue groups. Mean jitter, percentage of pathologic fibers, and percentage of blocked fibers of the EDC muscle were significantly higher in the pseudobotulism group than in the fatigue and control groups. There were no differences between groups for the OO muscle. The SFEMG results in the botulism group were qualitatively similar to those of the pseudobotulism group. Conclusions SFEMG of the EDC muscle confirmed diffusion of the toxin into muscles distant from the injection site in the pseudobotulism group. SFEMG in the OO muscle is not useful for the diagnosis of diffusion. No major signs of diffusion of botulinum toxin type A were found away from the injection site in patients with fatigue but no motor weakness. Such fatigue may be related to other mechanisms. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999315000404 |
Bibliothèques HE Vinci
