Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | Incidence of Neutropenia With Valproate and Quetiapine Combination Treatment in Subjects With Acquired Brain Injuries (2016) |
Auteurs : | Hee Jung Park ; Jung Yoon Kim |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2016/2, 2016) |
Article en page(s) : | pp. 183188 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Acide valproïque ; Neutropenie ; Rééducation et réadaptation |
Mots-clés: | Brain injuries ; Lésions encéphaliques ; Dibenzothiazepines ; Dibenzothiazépines ; Neutropenia ; Valproic acid |
Résumé : |
Objective To investigate whether the incidence of neutropenia was higher in subjects who received a combination treatment with valproate and quetiapine than in those who were administered monotherapy. Design Retrospective cohort study. Setting Rehabilitation department of a university hospital. Participants Patients with acquired brain injuries who had taken valproate for seizures or quetiapine for delirium for >7 days (N=101). Data were extracted from electronic medical records of the hospital. Interventions Not applicable. Main Outcome Measures Incidence of neutropenia (absolute neutrophil count Results The incidence of neutropenia was significantly higher in the group receiving the combination treatment than in those receiving the monotherapy (32.26% vs 12.90%, adjusted P=.036), despite a lack of any differences in the daily doses of the medications. Coadministration of quetiapine and valproate was the predictor of neutropenia development when age, body weight, and underlying diseases were adjusted in the logistic regression model (odds ratio=3.749; 95% confidence interval, 1.16112.099; P=.027). Conclusions Administration of quetiapine together with valproate in patients with acquired brain injury could increase the incidence of medication-induced neutropenia. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/science/article/pii/S0003999315011946 |