Login
Communauté Vinci
Extérieur
Si votre nom d'utilisateur ne se termine pas par @vinci.be ou @student.vinci.be, utilisez le formulaire ci-dessous pour accéder à votre compte de lecteur.
Titre : | Cognitive Reserve and Symptom Experience in Multiple Sclerosis: A Buffer to Disability Progression Over Time? (2013) |
Auteurs : | Carolyn E. Schwartz ; Brian R. Quaranto ; Brian C. Healy ; et al. |
Type de document : | Article |
Dans : | Archives of Physical Medicine and Rehabilitation (2013/10, 2013) |
Article en page(s) : | pp. 1971-1981 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Personnes handicapées ; Rééducation et réadaptation ; Sclérose en plaques ; Signes et symptômes |
Mots-clés: | Cognitive Reserve ; Réserve cognitive ; Multiple Sclerosis ; Disabled Persons ; Natural History ; Histoire naturelle ; Chronic Progressive ; Sclérose en plaques chronique progressive ; Signs and Symptoms |
Résumé : |
Objective To investigate the possible buffering effect of cognitive reserve on symptom experience for multiple sclerosis (MS) disease course. Design Secondary analysis of longitudinal data from the North American Research Committee on MS Registry. Setting Registry study and web-based supplemental survey. Participants People with MS (N=859). Interventions Not applicable. Main Outcome Measures Two health outcome measures, the Symptom Inventory and the Performance Scales, were collected biannually over 1 and 6 years, respectively. Active and passive cognitive reserve was measured using the Stern Leisure Activities and the Sole-Padulles Childhood Enrichment tools, respectively. Linear regression, chi-square, multilevel random-effects modeling, and classification and regression tree modeling were used to compare cross-sectional means, disease course by cognitive reserve, longitudinal trajectories, and active cognitive reserve item endorsement by disability groups, respectively. Results Patients with high-active reserve had a lesser symptom burden than those with low-active reserve independent of passive reserve (P<.01 cognitive reserve was associated with course of disease such that high-active patients were overrepresented among relapsing-remitting and underrepresented progressive p longitudinal modeling revealed a significant interaction active time in mobility fatigue overall disability the whole sample all comparisons whose trajectories changed over less deterioration passive evidenced no effect analyses. scores across groups had similar range but comprised different items indicating maintain activities as progresses.> Conclusions Our findings suggest that active cognitive reserve is a buffer for functional limitation across disability groupings. Cognitive reserve may provide an alternative lens for thinking about the disease course of MS, providing a longer runway until disability accrual through cortical remodeling. Loss of cognitive reserve may explain the onset of progressive disease in MS. |
Disponible en ligne : | Oui |
En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/journal/archives-of-physical-medicine-and-rehabilitation |