| Titre : | Pilot Study: Elevated Circulating Levels of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor in Patients With Chronic Spinal Cord Injury (2013) |
| Auteurs : | Adam Stein ; Arti Panjwani ; Cristina Sison ; et al. |
| Type de document : | Article |
| Dans : | Archives of Physical Medicine and Rehabilitation (2013/8, 2013) |
| Article en page(s) : | pp. 1498-1507 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Inflammation ; Rééducation et réadaptation ; Traumatismes de la moelle épinière |
| Mots-clés: | Cytokines ; Macrophage migration-inhibitory factors ; Facteurs inhibiteurs de la migration des macrophages ; Spinal cord injuries |
| Résumé : |
Objective To test the hypothesis that the proinflammatory cytokine macrophage migration inhibitory factor (MIF) is elevated in the circulation of patients with chronic spinal cord injury (SCI) relative to uninjured subjects, and secondarily to identify additional immune mediators that are elevated in subjects with chronic SCI. Design Prospective, observational pilot study. Setting Outpatient clinic of a department of physical medicine and rehabilitation and research institute in an academic medical center. Participants Individuals with chronic (>1y from initial injury) SCI (n=22) and age- and sex-matched uninjured subjects (n=19). Interventions Not applicable. Main Outcome Measures Plasma levels of MIF, as determined by a commercially available multiplex suspension immunoassay. The relationship between MIF levels and clinical/demographic variables was also examined. As a secondary outcome, we evaluated other cytokines, chemokines, and growth factors. Results Plasma MIF levels were significantly higher in subjects with chronic SCI than in control subjects (P<.001 elevated mif levels were not correlated significantly with any one clinical or demographic characteristic. subjects sci also exhibited higher plasma of monokine induced by interferon-gamma c-x-c motif ligand macrophage colony stimulating factor interleukin-3 and stem cell growth beta among the scgf- increased time from initial injury.> Conclusions These data confirm the hypothesis that MIF is elevated in subjects with chronic SCI and identify additional novel immune mediators that are also elevated in these subjects. This study suggests the importance of examining the potential functional roles of MIF and other immune factors in subjects with chronic SCI. |
| Disponible en ligne : | Oui |
| En ligne : | https://login.ezproxy.vinci.be/login?url=https://www.sciencedirect.com/journal/archives-of-physical-medicine-and-rehabilitation |
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