| Titre : | Further Assessment to Determine the Additive Effect of Botulinum Toxin Type A on an Upper Extremity Exercise Program to Enhance Function Among Individuals With Chronic Stroke but Extensor Capability (2012) |
| Auteurs : | S.L. Wolf ; B. Milton ; A. Reiss |
| Type de document : | Article |
| Dans : | Archives of Physical Medicine and Rehabilitation (2012/4, 2012) |
| Article en page(s) : | pp 578-587 |
| Langues: | Anglais |
| Descripteurs : |
HE Vinci Accident vasculaire cérébral (AVC) ; Exercice physique ; Membre supérieur ; Rééducation et réadaptation |
| Mots-clés: | Arm ; Botulinum toxin ; Cerebrovascular accident ; Exercise ; Toxines botuliniques |
| Résumé : |
Objective To determine whether dose-specified botulinum toxin type A (BTX-A) and a standardized exercise protocol produce better upper extremity function than placebo and the same exercise program. Design Double-blind randomized trial. Setting A rehabilitation research center. Participants A convenience sample of patients (N=25, age range, 23–76y) who sustained a stroke 3 to 24 months previously but could initiate wrist extension. Interventions Participants were randomly selected to receive either BTX-A (maximum 300U) or saline, followed by 12 to 16 exercise sessions. Main Outcome Measures The primary outcome was the Wolf Motor Function Test (WMFT). Secondary outcome measures included the Modified Ashworth Scale (MAS), active range of motion, and the Stroke Impact Scale (SIS; quality of life). Results There were no group-by-time interactions for changes in the WMFT and no treatment difference (P=.86), although the BTX-A group could complete more tasks governing proximal joint motions. MAS scores improved for the BTX-A group and worsened for the control group after injection (P=.02), as did the SIS emotion domain (P=.035). Conclusions Among chronic stroke survivors, BTX-A did not impact function, movement, or tone more than a standardized exercise program. |
| Disponible en ligne : | Oui |
| En ligne : | http://www.archives-pmr.org/article/S0003-9993%2811%2900974-9/abstract |
Bibliothèques HE Vinci
