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Titre : | Diet-related DNA adduct formation in relation to carcinogenesis (2016) |
Auteurs : | Lieselot Hemeryck ; Lynn Vanhaecke |
Type de document : | Article |
Dans : | Nutrition reviews (vol 74, n° 8, 2016) |
Article en page(s) : | 475-489 |
Langues: | Anglais |
Descripteurs : |
HE Vinci Aliments ; Altération de l'ADN ; Carcinogenèse ; Risque ; Tumeurs |
Mots-clés: | contaminants alimentaires |
Résumé : | The human diet contributes significantly to the initiation and promotion of carcinogenesis. It has become clear that the human diet contains several groups of natural foodborne chemicals that are at least in part responsible for the genotoxic, mutagenic, and carcinogenic potential of certain foodstuffs. Electrophilic chemicals are prone to attack nucleophilic sites in DNA, resulting in the formation of altered nucleobases, also known as DNA adducts. Since DNA adduct formation is believed to signal the onset of chemically induced carcinogenesis, the DNA adduct-inducing potential of certain foodstuffs has been investigated to gain more insight into diet-related pathways of carcinogenesis. Many studies have investigated diet-related DNA adduct formation. This review summarizes work on known or suspected dietary carcinogens and the role of DNA adduct formation in hypothesized carcinogenesis pathways. |
Disponible en ligne : | Non |
Exemplaires (1)
Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|
Nutrition reviews. vol 74, n° 8 (2016) | Périodique papier | Woluwe | Espace revues | Consultation sur place uniquement Exclu du prêt |